2024–2025
Medical
Laboratory Science
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WHAT’S INSIDE
Med Lab Science Library .......................................... 3 Hematology . ................................................................. 4 Phlebotomy . ................................................................. 5 Urinalysis . ...................................................................... 6 Immunology . ................................................................ 6 Laboratory & Operations Management . ........... 7 Microbiology ................................................................ 8
Molecular Diagnostics .............................................. 8 Math ................................................................................ 9 Research ......................................................................... 9 Course Review & Exam Prep ................................ 10 General Resources . .................................................. 11 Medical Terminology ............................................... 12
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Chapter 3 • Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology 37
36 Part I • Basic Hematology Principles
the red blood cell to survive for its 120-day life cycle, the following conditions are necessary: • The red blood cell membrane must be deformable, able to squeeze though smaller diameter blood vessels • Hemoglobin structure and function must be adequate • The red blood cell membrane must maintain osmotic balance and permeability The mature red blood cell is an anucleate structure with no capacity to synthesize protein, but it is capable of a limited metabolism that enables it to survive for 120 days. 3 An intact, competent, and fully functioning red blood cell membrane is an essential ingredient to a successful red blood cell life span. The membrane of the red blood cell is a trilaminar and three-dimensional structure containing glycolipids and glycoproteins on the outermost layer directly beneath the red blood cell membrane surface. Cholesterol and phospholipids form the central layer, and the inner layer, the cytoskeleton, contains the specific membrane proteins: spectrin, ankyrin, actin, and protein 4.1 (Fig. 3.8). Composition of Lipids in the Interior and Exterior Layers Fifty percent of the red blood cell membrane is protein, 40% is lipid, and the remaining 10% is cholesterol (Box 3.1). The lipid fraction is a two-dimensional interactive fluid that serves as a barrier to most water-soluble
RED BLOOD CELL MEMBRANE DEVELOPMENT AND FUNCTION
The mature red blood cell is a magnificently designed instrument for hemoglobin delivery. As a hemoglobin- filled sac, the red blood cell travels more than 300 miles through the peripheral circulation, submitting itself to the swift waters of the circulatory system, squeezing through the threadlike splenic sinuses, and bathing in the plasma microenvironment. Cellular and environ- mental factors contribute to red blood cell survival. For
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FIGURE 3.3 Basophilic normoblast. From Glassy EF, ed. Color Atlas of Hematology: An Illustrated Field Guide Based on Proficiency Testing. Northfield, IL: College of American Pathologists; 1998. Reproduced with permission.
FIGURE 3.4 Polychromatophilic normoblast. Courtesy of Bernardino Madsen, Casper College, Casper, Wyoming.
• Polychromatophilic normoblast (Fig. 3.4) Size: 13 μ m N:C ratio: 4:1 Nuclear chromatin: Condensed, moderately compacted, smaller in amount, deeper texture Cytoplasm: Color mixture, blue layered with tinges of orange-red, “the dawn of hemoglobinization” as hemoglobin begins to be synthesized, more cytoplasm • Orthochromic normoblast (Fig. 3.5) Size: 8 μ m N:C ratio: 1:1 Nuclear chromatin: Dense, velvet-appearing homogeneous chromatin, baseball round in appearance Cytoplasm: Increased amount with noticeable color change, with orange-red color tinges with slight blue tone • Reticulocyte (polychromatic macrocyte) (Fig. 3.6) Size: 8 μ m Appearance: Remnant of RNA visualized as reticulum, filamentous structure in chains or as a single dotted structure in new methylene
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FIGURE 3.7 Normal red blood cell. Note discocyte shape and small area of central pallor. Courtesy of Kathleen Finnegan, Stony Brook University, Stony Brook, New York.
FIGURE 3.5 Orthochromic normoblast. Courtesy of Kathleen Finnegan, Stony Brook University, Stony Brook, New York.
Antigen
GpA
Protein
Membrane surface
GpB
Lipid bilayer
Membrane cytoskeleton
blue stain, seen in Wright’s stain as large bluish red blood cells, polychromatophilic macrocytes
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• Mature red blood cell (Fig. 3.7) Size: 6 to 8 μ m Appearance: Disk-shaped cell filled with
Actin
Spectrin dimer-dimer interaction
Ankyrin
Adducin
Spectrin
Protein 4.1
hemoglobin, having an area of central pallor of 1 to 3 μ m
FIGURE 3.8 Red blood cell membrane. Note placement of integral proteins (glycophorins GpA and GpB) versus peripheral proteins (spectrin and ankyrin).
FIGURE 3.6 Reticulocyte with new methylene blue. Courtesy of Bernardino Madsen, Casper College, Casper, Wyoming.
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HEMATOLOGY
Hematology In Practice, 3rd Edition Betty Ciesla, MS, MT(ASCP) SH CM Basic principles of hematology made memorable
MLS LIBRARY
A unique visual language simplifies practical laboratory principles and procedures into easy-to-follow, manageable sections. Your students will begin with the basic principles of hematology; discover red and white blood cell disorders; journey through hemostasis and disorders of coagulation; and then explore the procedures needed in the laboratory. The acute leukemia and myeloproliferative chapters reflect World Health Organization (WHO) categories. Student “Alerts” highlight critical values and other important information that students must be able to recognize in the laboratory. “Deeper Understanding” boxes provide additional theory on specific topics. Case studies illustrate key principles of each major concept.
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432 pages | 231 illustrations Hard cover | 2019 $118.95 (US) ISBN-13: 978-0-8036-6824-9
Clinical Hematology and Fundamentals of Hemostasis, 6th Edition Denise M. Harmening, PhD, MLS(ASCP)
MLS LIBRARY
Redesigned to meet the needs of today’s medical laboratory science programs This classic text masterfully presents the basic principles of hematology and the fundamentals of hemostasis. A full-color text, lab manual & atlas—all in one! NEW! Critical-Thinking Questions interspersed within chapters encourage students to assess their understanding of the content. NEW! Glossary terms appear in bold and acronyms are spelled out the first time they are used. NEW & UPDATED! Laboratory methods for routine hematology tests, coagulation, automated differential analysis, flow cytometry, and more, appear in the book with detailed, step-by-step instructions online for maximum flexibility. NEW! “Advanced Concept” boxes designate content that is higher level for many medical laboratory programs, such as treatment-oriented information. More than 900 full-color illustrations, diagrams, charts, and boxes help students master difficult concepts and procedures. “Summary Charts” collect critical points from the chapters to serve as a review tool. “Case Studies” present realistic scenarios and include questions regarding interpretation of laboratory findings to promote critical thinking. Review Questions assess mastery of the Learning Objectives.
912 pages | 920 illustrations Hard cover | 2024 $177.95 (US) ISBN-13: 978-0-8036-9443-9
Instructor § eBook § Instructor’s Guide § Image Bank § Test Bank § PowerPoints § Critical-Thinking Case Studies § Laboratory Procedures Student § Critical-Thinking Case Studies § Laboratory Procedures
My lifeline. “Without this book learning hematology would and could have been so much harder.” —Online Student Reviewer
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PHLEBOTOMY
Blood Collection for Healthcare Professionals , A Short Course, 4th Edition Marjorie Di Lorenzo, MT(ASCP)SH Susan King Strasinger, DA, MT(ASCP)
MLS LIBRARY
Perfect for a short module on phlebotomy Here’s “to-the-point” instruction on the whys and hows of blood collection techniques. Case Studies throughout the text challenge students to apply knowledge to realistic patient situations, while videos online at FADavis.com demonstrate proper techniques.
NEW & UPDATED! Content that reflects science and practice today NEW! Photographs and illustrations in the chapter, Dermal Puncture
288 pages | 207 Illustrations Soft cover l 2022 $62.95 (US) ISBN-13: 978-1-7196-4599-7
EXPANDED! Discussions of cultural competence in the context of greeting the patient Venipuncture, dermal puncture, and special collections, including from vascular access devices as well as order of draw, vein selection and alternate sites Full-color photographs and drawings that show procedural steps and critical anatomy Guide to collection tubes and additives Test-specific collection and handling guidelines as well as how to address complications and troubleshooting
Instructor § eBook
§ Instructor’s Resource Guide § Test Bank & Image Bank § PowerPoints § Videos § Animations § Quiz Show PowerPoints § Comprehensive Practice Exam Student § Videos § Animations
I like this book because it’s easy to work with and explain[s] in simple form. “Great book for short-term training, it’s perfect.” —Lisa W., Online Reviewer
The Phlebotomy Textbook, 4th Edition Susan King Strasinger, DA, MT(ASCP) Marjorie Schaub Di Lorenzo, MT(ASCP)SH Whys & hows to safely obtain quality samples Make important concepts easy to understand with a friendly, narrative writing style, over 400 images, and clinical situations to encourage critical thinking. Integrates theory and procedures with a focus on pre-examination variables and safety procedures. Online video library that includes point-of-care testing, venipuncture and dermal puncture procedures, and safety
MLS LIBRARY
Instructor § eBook § Instructor’s Guide § Image Bank & Test Bank § PowerPoints § Procedural Videos § Animations Student § Procedural Videos § Animations
552 pages | 435 illustrations Soft cover | 2019 $83.95 (US) ISBN-13: 978-0-8036-6842-3
Visual reinforcement through boxes, tables, highlighted technical and safety tips, alerts, and pre-examination considerations
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PHLEBOTOMY
Great resource to recommend to your students!
VERY HELPFUL & CONVENIENT!! “This handbook is great, there’s pictures and it’s all straight to the point. Easy to read and understand! Also can fit in your scrubs pocket or back pocket!” —Krystina, Online Reviewer
$41.95 (US) | ISBN-13: 978-0-8036-7565-0
URINALYSIS
Urinalysis and Body Fluids, 7th Edition Susan King Strasinger, DA, MT(ASCP) | Marjorie Schaub Di Lorenzo, MT(ASCP)SH
MLS LIBRARY
The classic text—now with more full-color images Give your students the theoretical and practical knowledge they need to confidently handle and analyze non-blood body fluids, and to keep themselves and their laboratory safe from infectious agents.
432 pages | 1,577 illustrations Soft cover | 2021 $82.95 (US) ISBN-13: 978-0-8036-7582-7
Helpful and useful. “Excellent book! Very helpful. The images were spot on and the descriptions were easy to read. I recommend for any body fluids class.” —Felicia W., Online Student Reviewer
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IMMUNOLOGY
Clinical Immunology and Serology A Laboratory Perspective, 5th Edition Linda E. Miller, PhD, I, MB CM (ASCP)SI | Christine Dorresteyn Stevens, EdD, MT(ASCP) Practical. Easy to read. Student friendly. This practical introduction to clinical immunology covers the essential theoretical principles and the serology techniques most commonly used in the laboratory.
648 pages | 231 illustrations | Soft cover | 2021 $104.95 (US) ISBN-13: 978-0-8036-9440-8
Great immunology book! “This book is very detailed but also very well explained. Overall, a must-have to anyone in an immunology class.” —Online Student Reviewer
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IMMUNOHEMATOLOGY
Modern Blood Banking & Transfusion Practices, 7th Edition Denise M. Harmening, PhD, MT(ASCP) The perfect balance of theory & practice.
MLS LIBRARY
Building from a review of the basic sciences to the how and why of clinical practice, this popular text continues to set the standard for developing a comprehensive understanding of modern routine blood banking and transfusion practices.
688 pages | 310 illustrations | Hard cover | 2019 $146.95 (US) ISBN-13: 978-0-8036-6888-1
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LABORATORY & OPERATIONS MANAGEMENT
Laboratory Operations and Management Foundations of Practice Jeanne M. Isabel, EdD, MLS (ASCP) CM SH(ASCP) CM Patricia J. Ellinger, MSEd, MASCP, MLS(ASCP) CM SBB CM Dana M. Griffin, MBA, MLS(ASCP) CM Management and lab operations for the entry-level student!
NEW!
MLS LIBRARY
This new text introduces the principles of laboratory management and demonstrates their application in professional practice. It builds a foundation in the administration of personnel and finances and presents quality measures, compliance, safety regulations, and professionalism— information critical for all laboratory personnel, including the new supervisor. Meets students where they are. Addresses the entry-level management, education, and laboratory operations content required by certification and accreditation standards. Explores other aspects of professionalism, including communication, ethics, leadership, and evidence-based practice. Engages readers with real-life examples and activities that introduce the day-to-day responsibilities of a laboratory manager, including… • “Setting the Scene,” a lab-based scenario that opens each chapter • “That’s a Wrap,” a summary of key points at the end of each chapter that also brings a conclusion to the opening scenario • “Stop and Think,” a question or situation that invites the reader to come to their own conclusions about the best way to resolve the issue at hand • “Tales from the Lab,” stories based on the authors’ experiences that demonstrate problem-solving in the workplace • “Play the Part,” role-playing exercises that help readers to develop their skills by proposing solutions or next steps for solving a problem Emphasizes ‘learning by doing’ to help readers apply content through practical applications. Makes learning easier with learning objectives, key terms, assignments, summaries of the main concepts, and review questions for each chapter.
About 416 pages │ 60 illustrations Soft cover │ Late 2024 About $79.95 (US) ISBN-13: 978-1-7196-4690-1
Instructor § eBook § Instructor’s Guide § Test Bank § PowerPoints CONTENTS IN BRIEF I. Professional Development and Education Principles II. Laboratory Organization and Function III. Laboratory Operations IV. Workforce Management V. Financial Management Appendices Glossary Index
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MICROBIOLOGY
Medical Parasitology A Self-Instructional Text, 7th Edition Ruth Leventhal, PhD, MBA, MLS(ASCP) Russell F. Cheadle, MS, MLS(ASCP) Diagnostically important parasites in a concise format
MLS LIBRARY
This classic text presents a systematic introduction to the biology and epidemiology of human parasitic disease. Detailed drawings and color photographs help students learn to recognize the diagnostic stages of parasites, to understand their life cycles, and to correlate the parasite with the diseases they cause. Within each chapter, case studies with application questions, short-answer review questions, multiple-choice questions, and other pedagogical methods help students learn the content and apply it to laboratory practice. New organization of protozoa! Four shorter chapters, one for each of the major protozoan groups: Amoebida, Intestinal Flagellates and Ciliates, the Hemoflagellates Trypanosoma spp . and Leishmania spp ., and Sporozoa Expanded art program including photos of common artifacts, blood parasites, and arthropods New information on parasites that have become medically relevant, such as Plasmodium knowlesi and the Asian tick Updated coverage of the symptomatology, pathology, and treatment of parasitic diseases Updated laboratory procedures to conform to current quality control standards Enhanced Instructor resources online to help you engage students and encourage critical thinking
312 pages | Soft cover | 2020 $86.95 (US) ISBN-13: 978-0-8036-7579-7
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§ Test Bank & Image Bank § Audio Pronunciations
MOLECULAR DIAGNOSTICS
Molecular Diagnostics Fundamentals, Methods & Clinical Applications, 3rd Edition
MLS LIBRARY
Lela Buckingham, PhD, MB(ASCP), DLM(ASCP) Clinical application of molecular concepts
Effectively introduce your students to the fundamentals of nucleic acid biochemistry and the advanced concepts integral to diagnostic testing in today’s laboratories. Show them how to apply molecular techniques in clinical laboratory practice, including microbiology, virology, genetics, oncology, and human identification. Expanded discussion of nucleic acid sequencing, with added emphasis on next generation sequencing (NGS) New material on proteomics and mass spectrometry applications
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576 pages | 386 illustrations Soft cover | 2019 $88.95 (US) ISBN-13: 978-0-8036-6829-4
The only book you need to become certified! “Excellent book, full of details and clinical information. In addition, it describes very complex concepts in a very easy way to understand including comprehensive diagrams.” —Ruben B.G., Online Reviewer
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PHLEBOTOMY MATH
Fundamental Laboratory Mathematics Required Calculations for the Medical Laboratory Professional Lela Buckingham, PhD, MB(ASCP), DLM(ASCP) Are your students confident calculating lab math?
MLS LIBRARY
Nearly 600 practice problems with answers show them the calculations required in the clinical laboratory for enzyme chemistry, hematology, urinalysis, molecular biology, and molecular diagnostics. Problem sets in each chapter show all the work performed in each calculation. “Application” problems ask your students to apply math in a clinical context. “Caution” boxes highlight common sources of error in calculations or procedures.
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352 pages | 30 illustrations eBook only
Available only in the Med Lab Science Library collection on FADavis.com
RESEARCH
NEW EDITION!
Bailey’s Research for the Health Professional, 4th Edition Angela N. Hissong, DEd, OTR/L, CMCP, CMMT Jennifer E. Lape, OTD, OTR/L Practical guide to research and evidence-based practice
MLS LIBRARY
Research is a dynamic journey. This text leads your students through a research or evidence- based practice project—from crafting a research question and selecting an appropriate methodology to disseminating findings. NEW! Integrates research and evidence-based practice with more examples and templates Easy-to-follow guidance through the process • Getting started . Differentiating research and evidence-based practice, identifying a topic, and completing a literature search • Understanding & Appraising Research . Quantitative, qualitative, mixed methods, and systematic review research designs, and the sampling, data collection tools, and analysis methods relative to each design • Designing Your Inquiry . Developing an inquiry plan, designing a survey, drafting an
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About 352 pages| 46 Illustrations Soft cover | Early 2025 About $74.95 (US) ISBN-13: 978-1-7196-4868-4
AVAILABLE NOW! Bailey’s Research for the Health Professional, 3rd Edition $68.95 (US) ISBN-13: 978-0-8036-3916-4
institutional review board proposal, and identifying and securing funding • Disseminating Outcomes . Sharing findings through various outlets
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COURSE REVIEW & EXAM PREP
Featuring DAVIS EDGE
Medical Laboratory Science Review, 5th Edition Robert R. Harr, MS, MLS(ASCP) The best MLS & MLT exam-prep on the market—3,260 questions in all! When your students purchase Medical Laboratory Science Review, 5th Edition, they receive FREE access to Davis Edge for a full year. No other single review product offers this much value. The Text Multiple-choice questions with detailed rationales that categorize each question by subject category, task, and taxonomy level Problem-solving sections in each chapter to reinforce the practical application of material A photomicrograph-based exam and mock certification exam Davis Edge Online Q&A Students can use Edge for self study; faculty can also use Edge to create graded assignments 1,000 questions Immediate feedback for correct and incorrect responses “Comprehensive Exam Builder” “Quiz Builder” to select practice questions by content area
Print Text + Access to DavisEdge.com 616 pages | 64 illustrations Soft cover | 2019 $83.95 (US) ISBN-13: 978-0-8036-6827-0 Or purchase directly at FADavis.com
Instructor § Davis Edge § eBook Student § Davis Edge
Perfect for remembering everything you need. “Tons of questions with explanations. Color plate section for mycology, hematology, urinalysis, and biochemistry. It has an access code for practice more than 1000 additional questions online! I’m pretty sure that this book is key in your study for the ASCP certification.” —Jay D., Online Reviewer
Questions provide the additional practice students need to master must-know content while building exam confidence.
Rationales provide students with immediate feedback for on-the-spot remediation that explains why their responses are correct or incorrect.
See how Davis Edge can work for you and your students. Contact us at Hello@FADavis.com
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COURSE REVIEW & EXAM PREP
Quick Review Cards for Medical Laboratory Science, 3rd Edition Valerie Polanksy, MEd, MLS(ASCP) | Nadine M. Lerret, Ph.D., MLS(ASCP) CM
A complete study guide! More than 300 quick-reference, two-sided, 4” x 6” cards offer concise, yet complete coverage of the entire curriculum and all of the disciplines covered on the Board of Certification’s content outline. Perfect for review before classroom tests and licensure exams, and during clinical rotations. NEW & UPDATED! Content that aligns with the BOC exam and the latest scientific information and changes in practice UPDATED & REVISED! Reorganized Clinical Hematology and Microbiology sections that reflect the major reclassifications in these fields. UPDATED, REVISED & REORGANIZED! Molecular diagnostic clinical applications and procedures integrated into the core laboratory section complement the Molecular Diagnostics section that covers principles and methodologies. NEW! Cards with 10 multiple-choice questions (with answers) in each section of the deck, 80 questions in all. NEW! SI units to make conversions easier.
335 cards 111 illustrations 2022 $68.95 (US) ISBN-13: 978-0-8036-7569-8
Instructor § eBook
Perfect for BOC Review. “These cards perfectly summarize all of my courses and need-to-know info for my BOC.” —Morgan N., Online Reviewer
GENERAL RESOURCES
Visit FADavis.com for a complete list of our Davis’s Notes
“I have referred all my classmates to purchase these excellent resources. Even my instructor was impressed with it. You will not find more handy and complete pocket guides.” —Online Reviewer
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Turning Terminology into Language Medical Language Lab is the immersive, online platform that offers automatic grading for instructors and engages your students.
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Combine the power of Medical Language Lab with the text that meets your needs.
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of instructors say MLL helped their students prepare for course exams of students said MLL helped them develop their pronunciation of med terms
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